Once an eruption occurs, a large CO₂ cloud forms above the lake and expands to the neighbouring region. Because CO₂ is denser than air, it has a tendency to sink to the ground while pushing breathable air up. As a result, life forms that need to breathe oxygen suffocate once the CO₂ cloud reaches them, as there is very little oxygen in the cloud. The CO₂ can make human bodily fluids very acidic, potentially causing CO₂ poisoning. As victims gasp for air they actually hurt themselves more by sucking in the CO₂ gas.

At Lake Nyos, the gas cloud descended from the lake into a nearby village where it settled, killing nearly everyone. In this eruption, some people as far as 25 km (15.5 miles) from the lake died. A change in skin color on some bodies led scientists to think that the gas cloud may have contained a dissolved acid such as hydrogen chloride as well, but that hypothesis is disputed. Many victims were found with blisters on their skin. This is believed to have been caused by pressure ulcers, which likely formed from the low levels of oxygen present in the blood of those asphyxiated by the carbon dioxide. Thousands of cattle and wild animals were also asphyxiated, but no official counts were made. On the other hand, vegetation nearby was mostly unaffected except for that which grew immediately adjacent to the lake. There the vegetation was damaged or destroyed by a 5-meter (16.4 ft.) tsunami from the violent eruption.

For a limnic eruption to occur, the lake must be nearly saturated with gas. In the two known cases, the major component was CO₂, however, in Lake Kivu, scientists are concerned about the concentrations of methane gas as well. This CO₂ may come from volcanic gas emitted from under the lake or from decomposition of organic material. Before a lake is saturated, it behaves like an unopened carbonated beverage (soft drink): the CO₂ is dissolved in the water. In both the lake and the soft drink, CO₂ dissolves much more readily at higher pressure. This is why bubbles in a can of soda only form after the drink is open; the pressure is released and the CO₂ comes out of solution. In the case of lakes, the bottom is at a much higher pressure; the deeper it is, the higher the pressure at the bottom. This means that huge amounts of CO₂ can be dissolved in large, deep lakes. Also, CO₂ dissolves more readily in cooler water, such as that at the bottom of a lake. A small rise in water temperature can lead to the release of a large amount of CO₂.

Once the lake is saturated with CO₂, it is very unstable. A trigger is all that is needed to set off an eruption. In the case of the 1986 eruption at Lake Nyos, landslides were the suspected triggers, but an actual volcanic eruption, an earthquake, or even wind and rain storms are other possible triggers. In any case, the trigger pushes some of the saturated water higher in the lake, where the pressure is insufficient to keep the CO₂ in solution. Bubbles start forming and the water is lifted even higher in the lake (buoyancy), where even more of the CO₂ comes out of solution. This process forms a column of gas. At this point the water at the bottom of this column is pulled up by suction, and it too loses its CO₂ in a runaway process. This eruption pours CO₂ into the air and can also displace water to form a tsunami.

There are several reasons this type of eruption is very rare. First, there must be a source of the CO₂, so only regions with volcanic activity are at risk. Second, temperate lakes, such as North America's Great Lakes, turn over each spring and fall as a result of seasonal air temperature changes, mixing water from the bottom and top of the lake, so CO₂ that builds up at the bottom of the lake is brought to the top where the pressure is too low for it to stay in solution and it escapes into the atmosphere. Finally, a lake must be quite deep to have enough pressure to dissolve large volumes of CO₂. So only in deep, stable, tropical, volcanic lakes such as Lake Nyos are limnic eruptions possible.

A limnic eruption or lake overturn, is a rare type of natural disaster in which carbon dioxide (CO₂) suddenly erupts from deep lake water, suffocating wildlife, livestock and humans. Such an eruption may also cause tsunamis in the lake as the rising CO₂ displaces water. Scientists believe landslides, volcanic activity, or explosions can trigger such an eruption. Lakes in which such activity occurs may be known as limnically active lakes or exploding lakes. Some features of limnically active lakes include:

• CO₂-saturated incoming water
• A cool lake bottom indicating an absence of direct volcanic interaction with lake waters
• An upper and lower thermal layer with differing CO₂ saturations
• Proximity to areas with volcanic activity

Scientists have recently determined, from investigations into the mass casualties in the 1980s at Lake Monoun and Lake Nyos, that limnic eruptions and volcanic eruptions, although indirectly related, are actually separate types of disaster events.