Tropical cyclones out at sea cause large waves, heavy rain, and high winds, disrupting international shipping and, at times, causing shipwrecks. Tropical cyclones stir up water, leaving a cool wake behind them, which causes the region to be less favorable for subsequent tropical cyclones. On land, strong winds can damage or destroy vehicles, buildings, bridges, and other outside objects, turning loose debris into deadly flying projectiles. The storm surge, or the increase in sea level due to the cyclone, is typically the worst effect from landfalling tropical cyclones, historically resulting in 90% of tropical cyclone deaths. The broad rotation of a landfalling tropical cyclone, and vertical wind shear at its periphery, spawns tornadoes. Tornadoes can also be spawned as a result of eyewall mesovortices, which persist until landfall.

Over the past two centuries, tropical cyclones have been responsible for the deaths of about 1.9 million people worldwide. Large areas of standing water caused by flooding lead to infection, as well as contributing to mosquito-borne illnesses. Crowded evacuees in shelters increase the risk of disease propagation. Tropical cyclones significantly interrupt infrastructure, leading to power outages, bridge destruction, and the hampering of reconstruction efforts.

Although cyclones take an enormous toll in lives and personal property, they may be important factors in the precipitation regimes of places they impact, as they may bring much-needed precipitation to otherwise dry regions. Tropical cyclones also help maintain the global heat balance by moving warm, moist tropical air to the middle latitudes and polar regions. The storm surge and winds of hurricanes may be destructive to human-made structures, but they also stir up the waters of coastal estuaries, which are typically important fish breeding locales. Tropical cyclone destruction spurs redevelopment, greatly increasing local property values.

The main effects of tropical cyclones include heavy rain, strong wind, large storm surges at landfall, and tornadoes. The destruction from a tropical cyclone depends mainly on its intensity, its size, and its location. Tropical cyclones act to remove forest canopy as well as change the landscape near coastal areas, by moving and reshaping sand dunes and causing extensive erosion along the coast. Even well inland, heavy rainfall can lead to mudslides and landslides in mountainous areas. Their effects can be sensed over time by studying the concentration of the Oxygen-18 isotope within caves within the vicinity of cyclones' paths.

After the cyclone has passed, devastation often continues. Standing water can cause the spread of disease, and transportation or communications infrastructure may have been destroyed, hampering clean-up and rescue efforts. Nearly two million people have died globally due to tropical cyclones. Despite their devastating effects, tropical cyclones are also beneficial, by potentially bringing rain to dry areas and moving heat from the tropics poleward. Out at sea, ships take advantage of their known characteristics by navigating through their weaker, western half.

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